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Медицинскую помощь в Челябинске оказывают 38 муниципальных организаций, в которых в 2016 году работало 10 441 человек. Число больничных коек составляет 14 900. Челябинская областная клиническая больница была открыта в 1938 году и в данный момент состоит из 9 корпусов, консультативная поликлиника больницы ведёт приём по 32 специальностям. Областной онкологический диспансер, организованный в 1969 году, в данный момент оборудован кибер-ножом и ПЭТ-центром. В 2010 открыт центр сердечно-сосудистой хирургии, где за 2013 год высокотехнологичную помощь получили 5094 пациента. Также в городе функционирует областной ожоговый центр, открытый в 1978 году.
Особенно тревожным, по словам главврача онкодиспансера Андрея Важенина, стоит в городе заболеваемость раком с показателем в 402 человека на 100 тыс. населения, что выше общероссийского уровня на 15 %. Данный показатель является одним из самых высоких в России, заболеваемость за последние 20 лет выросла в 2 раза, продолжая расти ежегодно на 3 %. Неблагоприятная ситуация в городе и с заболеваемостью туберкулёзом, показатель которого в 2015 году подскочил на 12 % и составил 50,4 человека на 100 тыс. населения, что выше среднероссийского уровня на 20 %. Удручающая ситуация по заболеваемости ВИЧ — Челябинская область занимает пятое место среди регионов России по данному показателю, который в 2015 году вырос на 11 % и составил 63,9 человек на 100 тыс. населения, что выше на 20 % среднероссийского показателя. Средняя продолжительность жизни составляет 70,3 года (мужчины — 64,2 года, женщины — 76,2 года).
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